Effect of Single Dose Fenofibrate as an Adjunct to Phototherapy on Unconjugated Neonatal Hyperbilirubinemia: A RCT

Background: Fenofibrate is used as an adjunct therapy to reduce bilirubin level and duration of phototherapy. This study was done determine the efficacy fenofibrate in treatment unconjugated neonatal hyperbilirubinemia.
 Materials & Method: Total 60 neonates were enrolled devided into two groups. In group A, a single dose oral (10mg/kg) given along with phototherapy, Group B only Blood samples collected every 24 hours for total indirect bilirubin. SGPT before after giving fenofibrate.
 Result: Baseline serum 16.86± 0.89 A 17.31± 1.19 B. After starting came down lower value 14.83 ± 0.95 mg/dl 15.73 1.32 48 it 12.85 1.06 14.20 1.24 respectively. (P-value 0.004 0.001). The mean time needed phototherapy 51.20 8.29 70.40± 6.08 shorter comparison control group. No side effects observed administration.
 Conclusion: Administration showed significant reduction phototherapy.
 BANGLADESH J CHILD HEALTH 2021; VOL 45 (2) : 89-93